In vitro studies are not only an essential first step toward testing your hypothesis, but these studies also provide valuable insight that allows one to better tailor subsequent in vivo studies. Study outcomes tend to be crucial to the development of medical devices, surgical instruments, procedures and novel therapies. In vitro studies also provide data that is important for proof-of-concept determination, function validation, and peer review manuscript preparation, FDA applications and clinical trials.
With access to three AAALAC certified animal facilities, a team of in-house surgeons, and more than 30 years of experience, the Bone and Joint Research Lab specializes in the development of medically-relevant technologies by performing large or small animal studies.
Well aware of the limitations in funding for private corporations and academic investigators, the Bone and Joint Research Lab (BJRL) offers to perform this work at rates that are highly competitive, while ensuring world-class results. More specifically, the Bone and Joint Research Lab provides a variety of services that translate medical technologies from bench top to bedside. These services include:
Project design/management Our team of investigators can tailor each project to meet the needs of an investigator(s) or private corporation(s). Projects are effectively guided in areas of animal modeling, surgical approach, implantation procedures, animal husbandry, ordering, cost analysis, implant processing, data analysis and reporting.
Power analysis/statistical analysis One of the most important aspects of a successful in vitro project is to perform accurate power analysis prior to experimentation. In addition to our investigators, the Bone and Joint Research Lab BJRL consults with Ph.D. level statisticians to provide power analysis to determine the number of animals samples necessary to accurately provide translational and clinically statistically relevant research data as well as post hoc statistical analysis for comparative analysis.
Infection studies In vitro studies requiring animal modeling for infection prevention, detection or treatment can be performed by the BJRL. Previous studies performed in our lab have focused on active release antimicrobial coatings for medical devices, phage therapies, percutaneous implants and other anti-infective investigations.
Microbiological analysis In addition to in-house microbiological processing, the BJRL has collaborations with ARUP Laboratories, one of the largest clinical reference laboratories in the world, as well as access to Nelson Labs, a world-renowned facility for processing microbiological samples‒just 20 minutes away from the BJRL. Furthermore, direct observation of planktonic bacteria and bacterial biofilms can be performed with scanning electron microscopy, semi-quantitative streak plates, or by direct quantification using agar plate growth.
Post experimental analysis The BJRL can process and analyze the interaction between cultured cells or tissues on any implant. For example, these samples can be analyzed histologically, by scanning electron microscopy, and by laser scanning confocal microscopy.
Data collection/preparation Our team of investigators can provide support in the analysis of data collected from each experiment as well as preparation of documents required for reports, manuscripts or other requirements.
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